selenium toxicity nails

Brittle hair & nails, gastro-intestinal upset, skin rashes, fatigue and irritability. Selenium toxicity from a misformulated dietary supplement, adverse health effects, and the temporal response in the nail biologic monitor. Selenium naturally appears in water and some foods. Selenium deficiency can lead to muscle, neurological, immunological, skin, nail, hair, and thyroid dysfunctions. High blood levels of selenium can result in selenosis, with gastrointestinal distress, hair loss, white spots on nails, fatigue, and irritability. Just so, why would selenium be high? Sufficient selenium levels prevent vitamin E deficiency and its complications. Selenium toxicity (rarely: hyperselenemia) is caused by excessive intake of the non-metallic element selenium (Se) in the diet. In 2008, mislabeled selenium supplements caused negative side effects in 201 people because the liquid supplement had 200 times the amount of selenium stated on the label. Industrial contamination. Learn more here. Symptoms can include diarrhea, a metallic taste in the mouth, nausea, brittle nails, hair loss, coughing and more. A hair test showed an elevated selenium level of 3.2 µg/g (reference 0.4−1.4) 6 weeks after her last dose. Despite the limited data on and rare occurrence of selenium toxicity in humans, chronic selenium poisoning has been well studied in animals. Stomach upsets, vomiting, nausea, diarrhea, metallic taste in mouth, and intestinal cramps are common finding in selenium toxicity. Selenium toxicity from a misformulated dietary supplement, adverse health effects, and the temporal response in the nail biologic monitor. Biotin and Selenium are amazing vitamins for supporting the maintenance of your hair, skin and nails and for that reason, are well worth incorporating into your daily routine. Selenium deficiency symptoms can include: hair loss, reproductive issues, muscle weakness, fatigue, brain fog and thyroid dysfunction. Chronic selenium poisoning usually develops when livestock consume seleniferous forages and grains containing 5–50 ppm of selenium for many weeks or months, although chronic exposure to high concentrations of inorganic selenium can also produce chronic selenosis. Selenium is a crucial nutrient for everyone's health. Arsenic is a naturally occurring metalloid found in drinking water and certain foods. Effect of Selenium on Brain Injury in Chickens with Subacute Arsenic Poisoning. Eating too many Brazil nuts may also lead to selenium toxicity. Acute selenium toxicity associated with a dietary supplement. Selenium supports various selenoproteins that have a known role in maintaining healthy hair and nails. In excess selenium is exceedingly toxic. These occurred in susceptible persons with intakes of 910 µg per day or more. Selenium Content per Ounce of Tuna. CHRONIC SELENIUM TOXICITY / SELENOSIS Changes to hair & nails Skin lesions Numbness Convulsions Paralysis Clinical Neurological effects Peripheral hypoaesthesia Acroparesthesiae Pain Hyperreflexia As a consequence of inadequate human cases of Selenosis, much of our knowledge is based on animal models. Selenium has an atomic weight of 78.971 and an atomic number of 34. Patient may complain of cough, typical garlic odor while breathing, inflammation in bronchial passage, shallow respiration, fluid in lungs. Selenium is an important mineral for many of your body's functions. While misformulation is uncommon, the consequences can be serious. The acute toxicity associated with oral selenium ingestion and the blood and urinary levels of selenium in different cases of poisonings were reviewed. case of selenium poisoning was defined as hair loss, nail dis-coloration or brittleness, or 2 or more of the following symp-toms: muscle or joint pains, headache, foul breath, fatigue/weakness, gastrointestinal symptoms, or cutaneous eruption.Symptom onset must have occurred within 2 weeks after theperson ingested a liquid dietary supplement manufactured by“Company A,” purchased after January 1, 2008. Listing is for Selenium and selenium compounds (other than hydrogen selenide). Symptoms associated with dietary selenium deficiency may be exacerbated in those of us with certain genetic variants. Concentrations in blood and urine reflect recent selenium intake. MNDs may be present in at-risk individuals who have impaired absorption or … Selenium deficiency can cause weakness, muscle pains and may contribute to heart disease, especially in young malnourished children. In humans, the initial symptoms are nausea, fatigue, and diarrhea. Later symptoms include skin lesions, nausea, diarrhea, skin rashes, irritability, fatigue and nervous system abnormalities. (2013) ^ Prevost N, English JC 3rd. Hair and nails reflect tissue Se levels over a wide range of dietary intakes. Thanks for your input. Additionally, selenium deficiency can make iodine deficiency worse. Selenium has been used in alternative medicine as an aid to treat Hashimoto's thyroiditis (an autoimmune disorder of the thyroid), and to treat high cholesterol. In total, 10 different clippings were analyzed at two different measurement positions. Taking too much selenium over time can lead to selenosis, which can cause hair loss, nail loss, nausea, irritability, fatigue and some nerve damage. Selenium Toxicity. 31 In toxicity we see hair loss and loss of the nails, and in toxicity this is where white spots, streaks and brittle nails have been best documented. The first symptoms of toxicity are hair and nail brittleness and garlic smell on the breath. Poor hair and nail growth are early signs that are probably the easiest to notice. Neurological Signs Research has shown vitamin B12 deficiency to cause brown-gray nail discoloration. People with nut allergies should take caution. 1983). The first symptoms of toxicity are hair and nail brittleness and garlic smell on the breath. Aftercare. However, eating too many Brazil nuts can cause selenium toxicity. After treatment with 100 μg/d of selenium for 8 weeks to improve the selenium deficiency, interestingly, the proximal part of the nails at the nail base gradually turned normal, and the whitish part moved toward the distal direction without changing in appearance or size (Figure, B). It can also cause muscle weakness and pain, loss of pigmentation in the skin and hair, macrocytosis (enlargement of red blood cells) and other conditions. Thyroid Dysfunction. Selenium at doses several thousand times the RDA can cause acute toxicity, and when ingested in gram quantities can be fatal. Arch Intern Med. Micronutrient deficiencies (MNDs) commonly lead to cutaneous abnormalities involving the skin, hair, and nails, and these cutaneous manifestations often provide clues to the existence of the underlying deficiency. Hair Loss - Selenium deficiency can also cause hair loss which means many people with hair loss use selenium. Just be sure that your dose isn't too high or you may cause the same problem. #2. Brittle Nails - Selenium toxicity can cause changes to your nail beds including discoloration in your nails. #3. Deficiency found to be the cause of Keshan disease and Kashin-beck disease Other symptoms include lesions of the skin and nervous system, nausea, diarrhea, skin rashes, mottled teeth, fatigue, irritability, and nervous system abnormalities. Selenium toxicity: a case of selenosis caused by a nutritional supplement. Selenium is used to treat or prevent selenium deficiency. Extrapolation from animal experiments suggests that 400 to 700 μg/day may be needed for cancer protection. The most common clinical signs of chronically high selenium intakes, or selenosis, are hair and nail loss or brittleness. First signs of chronic selenium toxicity include a garlic odor and metallic taste in the mouth and eventually hair loss and brittle nails. Selenium is also a part of the enzymes that deiodinate thyroid hormones. Just be sure that your dose isn't too high or you may cause the same problem. Description. Selenium Toxicity. Should I take selenium supplements? Selenium deficiency is also more likely to be prevalent in a community as a whole, rather than just sporadic cases. Selenium toxicity causes the hair to become brittle, hair loss, deformed and brittle nails, sloughing off of the nails, discoloration of the teeth, tooth decay and discolored skin. Olivamine® TotalHealth MultiVitamin contains 100 mcg (143% DV) of selenium per serving. Research has shown vitamin B12 deficiency to cause brown-gray nail discoloration. Selenium deficiency may be only one of several undetermined factors that might exacerbate the detrimental effects of iodine deficiency . Concentrations of selenium in blood and urine samples in non-fatal cases are close to those observed in fatal cases. Manifestations include hair loss, abnormal nails, dermatitis, peripheral neuropathy, nausea, diarrhea, fatigue, irritability, and a … Methods A case was defined as the onset of symptoms of selenium toxicity in a person within 2 weeks after ingesting a dietary supplement manufactured by “Company A,” purchased after January 1, 2008. Use of dietary supplements in the U.S. has increased steadily over the last 25 years. Selenium toxicity is generally not a widespread threat to humans. Selenium Sulfide is an inorganic salt. Signs of Deficiency and Toxicity Deficiency. Technical Supporting Document for Noncancer RELs, Appendix D3. The balancing act of selenium is very delicate. Selenium deficiency may cause the following symptoms: Poor growth. Selenium (Se) is a part of the enzyme glutathione peroxidase, which metabolizes hydroperoxides formed from polyunsaturated fatty acids. Selenium is a solid at atmospheric temperatures as it has a melting point of 430 F and a boiling point of 1265 F. Symptoms of selenium toxicity can include hair loss, brittle nails, red swollen skin on the hands or feet, numbness and tingling in the extremities, convulsions or paralysis. Selenium intakes marginally above the upper limit (400 micrograms per day) can cause selenosis, characterized by brittleness and loss of hair and nails. Selenium is a mineral found in the soil. Concentrations of selenium in blood and urine samples in non-fatal cases are close to those observed in fatal cases. Inorganic selenium (eg, selenite) is more likely to cause toxicity than organic forms (eg, selenomethionine). Nail copper concentrations are raised in Wilson′s disease. Another test your healthcare professional may do is test your levels of glutathione peroxidase or other selenoproteins that require selenium to function. Signs of selenium deficiency, selenium toxicity. 30 Additionally, biotin deficiency can increase the risk of fungal nail infections and subsequent nail plate discoloration. This disease occurred primarily in the mountainous regions of China, causing heart lesions. Selenium toxicity occurs due to industrial contamination of water supplies. Typically if it is suspected, either serum or “scalp hair” or nail selenium levels may be checked, and there is a good correlation between the 2 levels. A recent study reported a number of villages in the People's Republic of China, where high percentages of individuals had nail and hair loss, dermatitis, nausea, garlic odor on their breath, fatigue, irritability, and hyperreflexia (4). It's essential to thyroid hormone metabolism, reproduction, DNA synthesis, and it protects you from infection and damage resulting from oxidative stress. Gun bluing is 2% selenious acid, and ingestion can lead to death via selenium poisoning. Hair or nail samples can also be taken which gives a better indication of long-term selenium status. Nails: As a result of zinc deficiency the Nails may show white specks or nails that split easily may occur. Use of a commercial supplement, found to contain approximately 20 times the intended Se concentration, resulted in a Se concentration of 8.1 mg/kg of the complete feed. However, Se at low doses protects the plants from variety of abiotic stresses such as cold, drought, desiccation, and metal stress. Acute selenium toxicity associated with a dietary supplement. 18 White nails can be the result of anemia and pink or red nails may suggest malnutrition with several nutrient and vitamin deficiencies. Clinical features of selenosis (chronic toxicity) are hair and nail brittleness and loss, gastrointestinal disturbances, skin rash, garlic breath, fatigue, irritability, and nervous system abnormalities. Loss of hair and nails has occurred both among Chinese people whose diets were naturally high in selenium and in Americans taking supplements with too much selenium. serious selenium toxicity outbreak that has occurred in the U.S. We quantified selenium concentrations in the misformulated supplement products, measured the temporal response in the nail biologic monitor, and associated exposure to self-reported selenosis symptoms. Regina. Interestingly, thyroid problems are also a Sign of Selenium Deficiency as well! Chronic Selenium Toxicity. Nail arsenic levels can be used to diagnose arsenic poisoning. Chronic Reference Exposure Levels Comments: OEHHA 2008. Selenium toxicity can occur with acute or chronic ingestion of excess selenium. Our dog has had excessive rashes and itching , red blotchy skin , developed moles and we go tarantula licking as well! While people only need a very small amount, selenium … The Link Between Selenium Deficiency and Hair Loss. Selenium supplements for healthy hair and nails 'can increase risk of type-2 diabetes' By Daily Mail Reporter Updated: 08:16 EDT, 1 March 2012 Body Odour: Body odour can result when there is a of Zinc deficiency. Its electron configuration is 3d(10) 4s(2) 4p(4). Bone and Joint Health Selenium counters the inflammation associated with the progression of osteoarthritis and rheumatoid arthritis. Later signs: One of the later signs of selenium toxicity are fatigue- particularly because of thyroid and adrenal gland dysfunction. Very low selenium status in humans has been associated with a juvenile, multifocal myocarditis called Keshan disease and a chondrodystrophy called Kaschin–Beck disease.,, Chronic selenium toxicity leads to loss of hair and nails. In many cases, common problems such as brittle nails or hair that splits at the ends may be helped with a selenium supplement. January 5, 2019 at 12:47 am I would say yes!!! So maybe the nail changes aren't exactly the same but the fact that cirrhosis and changes to the nails are the key signs of deficiency and toxicity is a pretty remarkable parallel. Selenium is found in a variety of foods, especially Brazil nuts, bread, fish, meat and eggs. Symptoms of selenium toxicity include nausea; vomiting; nail discoloration, brittleness, and loss; hair loss; fatigue; irritability; and foul breath odor (often described as “garlic breath”). The most commonly used measures of selenium status are plasma and serum selenium concentrations. The growth rate of vitamin E- deficient rats was depressed by only 1 mg selenium as sodium selenite/kg of diet (Witting and Horwitt, 1964), and swine deficient in vitamin E and selenium were shown to be more susceptible to acute selenium toxicity than pigs fed diets supplemented with vitamin E and selenium (Van Vleet et al., 1974~. The Agency for Toxic Substances and Disease Registry assigned selenium a “minimal” risk level. locoweed.Selenium is a component of the amino acids selenocysteine and selenomethionine.In humans, selenium is a trace element nutrient that functions as cofactor for glutathione peroxidases and certain forms of thioredoxin reductase. few weeks and included changes in the hair, nails, and liver. Background Selenium is an element necessary for normal cellular function, but it can have toxic effects at high doses. Arch Intern Med. Selenium deficiency: Cases have been reported where the fingernails turned white in patients with low serum and urine Selenium levels. Nutrients. Selenium is a trace element and essential nutrient that is found mainly in meats, grains, and nuts — food sources that almost always provide enough selenium to meet our daily nutritional requirements. The acute toxicity associated with oral selenium ingestion and the blood and urinary levels of selenium in different cases of poisonings were reviewed. Some reasons for selenium deficiencies include drinking alcohol, smoking cigarettes, and taking birth control pills. [14] White nail discoloration has been reported in patients with selenium deficiency, who also receive IV feedings. In plants, it sometimes occurs in toxic amounts as forage, e.g. Chronic exposure to foods grown in soils containing high levels of selenium (significantly above the UL) can cause brittle hair and nails, gastrointestinal discomfort, skin rashes, halitosis, fatigue, and irritability. It's essential to thyroid hormone metabolism, reproduction, DNA synthesis, and it protects you from infection and damage resulting from oxidative stress. Selenium is an important trace mineral that is required by antioxidant enzymes throughout the body to neutralize damaging free radicals. Yes. Deficiency of copper may cause hypothyroidism (under-production of thyroid hormones) which can lead to dry brittle hair, hair loss, brittle nails, coarse dry pale skin, weight gain, intolerance to cold, fatigue, depression, irritability, poor memory, muscle or joint pain, constipation, decreased libido, heavy periods or menstrual irregularities. ^ MacFarquhar JK, et al. … In the body, the greatest concentration of selenium is in the liver, kidney, heart, nails, spleen and tooth enamel. With selenium deficiency, the bed of your fingernails will start to change color. Despite its critical role in many vital processes, selenium can also be harmful. At high doses (> 900 mcg/day), selenium causes toxicity. Selenium is a mineral that's naturally found in some of the foods we eat. Selenium is a trace element considered a micro-nutrient, meaning a nutrient needed in very small amounts, that is required as an essential cofactor for the antioxidant enzymes of the body to counteract the damaging effects of reactive oxygen in … The best sources include: Brazil nuts, eggs, sunflower seeds, liver, fish, turkey, chicken breast, chia seeds and mushrooms. Use restrictions (high), Persistence and bioaccumulation (moderate), Non-reproductive organ system toxicity (high), Ecotoxicology (low), and Occupational hazards (high) antidandruff agent, hair conditioning agent, antidandruff, and hair conditioning. Toxic levels of plasma selenium are not well defined. Analyses of hair or nail selenium content can be used to monitor longer-term intakes over months or years. Human selenium poisoning in a high-selenium area of China also produced adverse effects on the nails, skin, nervous system, and teeth (Yang et al. For your body to make use of the iodine you consume, you need to get an adequate amount of selenium. It is interesting that few people are aware of selenium toxicity- even though it is relatively EASY to have a selenium overdose and it occurs relatively frequently; yet it seems that just about EVERYONE is concerned about an Overdose on Nail clipping phantoms supplemented with arsenic and selenium to produce materials with 0, 5, 10, 15, and 20µg/g were used for calibration purposes. Many participants said that the nail issues, fatigue, and hair loss continued for at least 90 days. Epidemiology It is less common than selenium deficiency. Manifestations include hair loss, abnormal nails, dermatitis, peripheral neuropathy, nausea, diarrhea, fatigue, irritability, and a garlic odor of the breath. Selenium deficiency can result in cardiomyopathy, leading to congestive heart failure. Selenium is a mineral with a long and interesting history. Treatment of selenium deficiency Inorganic selenium (eg, selenite) is more likely to cause toxicity than organic forms (eg, selenomethionine). For a simple way to do this, have a cup of TEA+ Cleanse everyday and before you know it, you’ll have hair shiny enough to rival Kylie Jenner’s weave. Reply. Interactions. Simultaneous species analysis of arsenic, selenium, bromine, and iodine in bottled drinking water and fruit juice by high performance liquid chromatography-inductively coupled plasma mass spectrometry. Selenium and its effect on hair and nails. Selenium Content Every 3 oz. Since selenium is actually a micronutrient, we need very small amounts of it for our bodies to function properly. Treatment of selenium toxicity involves reducing selenium consumption. 30 Additionally, biotin deficiency can increase the risk of fungal nail infections and subsequent nail plate discoloration. Other symptoms of chronic selenium overdose are a metallic taste in the mouth, and a garlic scent on the breath. Brittle Nails - Selenium toxicity can cause changes to your nail beds including discoloration in your nails. #3. Fatigue - Fatigue and low energy may stem from thyroid problems which excess selenium may exacerbate. Gun bluing is 2% selenious acid, and ingestion can lead to death via selenium poisoning. Selenium is a critical nutrient for optimal health, but too much can be harmful. Selenium. Unfortunately there is a misconception that selenium deficiency rarely occurs in developed countries. However, in patients with clinical signs of chronic toxicity (hair loss and brittle nails), plasma concentration is likely to be very high, about 10 times the upper limit of normal. Selenium is a chemical element with the symbol Se and atomic number 34. Selenium toxicity causes the hair to become brittle, hair loss, deformed and brittle nails, sloughing off of the nails, discoloration of the teeth, tooth decay and discolored skin. However, extremely high selenium intake can result in diarrhea, fatigue, hair loss, joint pain, nail discoloration or brittleness, and nausea. within few weeks: hair loss, horizontal streaks on nails. Symptoms of selenosis (selenium excess) include brittle nails and hair, skin lesions and garlic odour on the breath. Too much selenium can also cause diarrhea and nausea, skin rashes, skin lesions, irritability and fatigue. Selenium deficiencies can occur when the blood isn’t able to properly absorb selenium. , Most selenium is in the form of selenomethionine in animal and human tissues. Selenium is a reactive nonmetal and sometimes an metalloid which is located in period four and group 16 of the periodic table. Other symptoms include; nausea, weakness, and diarrhea. Last Chronic REL Revision: 2001. Toxicity symptoms include hair loss, weakened nails, dermatitis, dental defects, gastrointestinal disorders, nervousness, mental depression, metallic taste, vomiting, and garlic odor of breath and sweat.

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